Wound care

HyaCare® provides a range of wound-healing benefits. These include:

• Reduced inflammation
• Faster healing
• Less scar formation

Sodium hyaluronate synthesis is up-regulated at sites of tissue injury (such as during wound healing). Thus, HA accumulation is enhanced immediately after injury and remains elevated during the inflammatory and early granulation/re-epithelialization stages of wound repair.

HyaCare has multiple functions during topical wound repair, particularly in the inflammatory and early granulation stages. For example, it interacts with fibrin clots and initially modulates host inflammatory cell infiltration into the inflamed site.

Inducing growth factors
HyaCare also induces production of growth factors and cytokines in inflammatory cells, fibroblasts, and keratinocytes, and it protects and presents growth factors involved in topical wound repair, such as platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF), to their cognate receptors.

Accelerated wound healing
HA acts as an antioxidant by scavenging radical oxygen species (ROS) from inflammatory cells, and thus functions to both stimulate and limit inflammation at the wound site. During the formation of granulation tissue, HA promotes migration of both keratinocytes and fibroblasts, regulates cell proliferation, and contributes to the structure of the provisional matrix of granulation tissue.

Downloads
"Comparative studies of various hyaluronic acids produced by microbial fermentation for potential topical ophthalmic applications"
Abstract (PDF 15 kb)
Publication (PDF 94 kb)

"New biosynthetic hyaluronic acid with well-defined molecular weight for improved wound healing"
Abstract (PDF 48 kb)
Poster (PDF 1.8 Mb)